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Reveromycin A
产品编号：BIA-R1078
产品规格：0.25 mg/1 mg
产品规格：0.25 mg/1 mg
Reveromycin A, the dominant analogue of a complex of spiroketals
isolated from a Streptomyces sp., is an inhibitor of the mitogenic
activity of epidermal growth factor (EGF). It is a G1 phase cell
cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase.
Reveromycin A displays antiproliferative behaviour against human
cell lines KB and K562, as well as potent antifungal activity. More
recently it has been shown to induce apoptosis in osteoclasts thus
inhibiting bone resorption.
CAS Number: 134615-37-5
Molecular Formula: C36H52O11
Molecular Weight: 660.8
Source: from Streptomyces sp.
Purity: >99% by HPLC
Reveromycin A
货号： BIA-R1078 包装规格: 0.25 mg, 1 mg
Reveromycin A，是主要的螺酮缩醇复合物的同系物，从链霉菌属中分离，是表皮生长因子的促有丝分裂活性的抑制剂。它是G1期细胞周期抑制剂，选择性的抑制异亮氨酰-tRNA合成酶。Reveromycin A能抑制人细胞系KB和K562的增殖，并具有抗真菌的活性。近研究显示Reveromycin A能诱导破骨细胞的凋亡从而抑制骨质吸收。
CAS 号: 134615-37-5
分子式: C36H52O11
分子量: 660.8
来源: 来自于链霉菌属
纯度: >99% by HPLC