Doramectin/多拉克汀
产品规格：5 mg/25 mg
Synonyms : UK67994, Dectomax
Specifications
CAS # : 117704-25-3
Molecular Formula : C50H74O14
Molecular Weight : 899.1
Source : Streptomyces sp., biosynthetic
Appearance : White solid
Purity : >95%
Storage : -20oC
Solubility : Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Application Notes
Doramectin is a biosynthetic avermectin derived from a mutant of the original Streptomyces avermitilis strain
supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic
for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords
greater hydrophobicity and longer biological half-life compared to avermectin. like the other
milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts
neurotransmission leading to paralysis and death of the parasite.
References
1. Novel avermectins produced by mutational biosynthesis. Duttom C. J. et al. J. Antibiot. 1991, 44, 357.
2. Doramectin - a novel avermectin. Vercruysse J. Vet. Parasitol. 1993, 49, 1.
Doramectin/多拉克汀