发送询价
Recombinant Human TGF-β2 （insect derived）
产品编号:
100-35
别名:
Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin
描述:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
* Manufactured using （BTI-Tn-5B1-4） cells under license from the Boyce Thompson Institute for Plant Research, Inc.
* Manufactured using （BTI-Tn-5B1-4） cells under license from the Boyce Thompson Institute for Plant Research, Inc.
氨基酸序列:
ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS
来源:
（BTI‐Tn‐5B1‐4） Hi‐5 Insect cells*
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
交叉反应:
Mouse, Rat
研究领域:
| 血管生成/ 心血管 | 细胞凋亡 | ||
| 癌症 | 免疫系统 | ||
| 炎症 | 增殖 | ||
| 干细胞及分化 | TGF超家族 | ||
| 创伤修复 | 过敏 |
原产国:
USA
仅用于研究。不适用于诊断或治疗。
*Manufactured using （BTI-Tn-5B1-4） cells under license from the Boyce Thompson Institute for Plant Research, Inc.
Recombinant Human TGF-β2 Peprotech原装
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