品牌:1293
(-)-Epigallocatechin Gallate (EGCG)
(-)-表没食子儿茶素没食子酸酯
产品信息
产品名称 |
产品编号 |
CAS NO. |
规格 |
价格(元) |
(-)-Epigallocatechin Gallate (EGCG) |
MZ3651-20MG |
989-51-5 |
20mg | 238 |
(-)-Epigallocatechin Gallate (EGCG) |
MZ3651-100MG |
989-51-5 |
100mg |
598 |
(-)-Epigallocatechin Gallate (EGCG) |
MZ3651-500MG |
989-51-5 |
500mg |
2188 |
产品描述
(-)-表没食子儿茶素没食子酸酯((-)-Epigallocatechin Gallate, EGCG),CAS NO. 989-51-5,是从绿茶中提取纯化的一种成分,是儿茶素类化合物中zui有效的活性成分,具有zui强的抗氧化、抗癌、抗突变和抗血管生成活性,已被用于多种肿瘤包括肝癌、胃癌、皮肤癌、乳xian癌和结肠癌等的化学预防研究中,也对许多病毒包括HCV、HIV-1、HSV-1、HSV-2、腺病毒等有抑制作用。EGCG属于一种天然的多酚黄酮类抗生素,能够抑制端粒酶(omerase)和DNA甲基转移酶(DNA methyltransferase),阻止EGF受体和HER-2受体的激活,也能抑制脂肪酸合成酶和谷氨酸脱氢酶的活性。是一种β-分泌酶抑制剂(IC50=1.6μM),能抑制淀粉样蛋白的组装,抑制由蛋白如Aβ,α-突触核蛋白和亨廷顿蛋白介导的淀粉样纤维的形成。能抑制细胞生长和选择性诱导A431和人胰腺癌细胞的凋亡。也是DNMT1抑制剂。
产品特性
- CAS NO:989-51-5
- 化学名:3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1- benzopyran-3-yl ester
- 同义名:Epigallocatechin gallate表没食子儿茶素没食子酸酯;Tea catechin儿茶素;NVP-XAA723;Teavigo;
- 分子式:C22H18O11
- 分子量:458.37 g/mol
- 纯度:≥98% (HPLC)
- 外观:类白色至白色粉末
- 溶解性:溶于H2O(5 mg/ml),DMSO(20 mg/ml),无水乙醇(45 mg/ml)
-
化学结构:
文献1,Rasheed NO et al. Nephro-toxic effects of intraperito 体内研究: 动物模型(Animal Model):Male Swiss albino mice weighing 25–30 g
药物配制(Preparation):Teavigo, a highly purified extract co 注射剂量(Dosages):Mice were randomly divided into 4 groups 8 mice each except group 4 in which 15 mice were used: Group 1 received saline served as normal control. Group 2 received a single dose of STZ (150 mg/kg, i.p) used as diabetic control. Group 3 received EGCG (100 mg/kg, i.p) dissolved in saline for 4 days. Group 4 received STZ as in group 2 then the diabetic animals were injected after 48 hrs with EGCG as in group 3. After 48 hrs of STZ injection, animals with blood glucose level ≥200 mg/dl were selected as diabetic animals.
给药途径(Administration):Intraperito |
文献2,Pan C et al. NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxid Med Cell Longev. 2017;2017:3172692. PMID: 28698767 体内研究: 动物模型(Animal Model):Eight-week-old male mice that was successfully induced as diabetic mice. 药物配制(Preparation):EGCG dissolved in normal saline 注射剂量(Dosages):The diabetic mice and age-matched controls were treated daily by subcutaneously injected EGCG (100 mg/kg ≥98%, dissolved in normal saline) or normal saline daily, for a total period of 24 weeks. Blood glucose was recorded on days 0, 28, 56, 84, 112, 140, and 168, after diabetes onset. 给药途径(Administration):Subcutaneous (s.c.) injection |
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EGCG 儿茶素类抗氧化剂
EGCG 儿茶素类抗氧化剂
EGCG 儿茶素类抗氧化剂